Overview section
- Main active substances
- Sildenafil citrate 100 mg combined with dapoxetine 100 mg in each tablet.
- This offering is for whom
- Adult people assigned male at birth who are managed for both erectile dysfunction and premature ejaculation. Not intended for women, children or athletic performance enhancement.
- Strength
- Fixed single strength: 100 mg sildenafil plus 100 mg dapoxetine per tablet only.
New to this medicine? Read what happens to make it work first, then see the administration timing with respect to recommendations for dose levels, and assess the Australian import regulations and legal requirements before you purchase or import any product.
Understanding the way this operates
Sildenafil is used as a PDE5 inhibitor. It enhances the normal blood vessel relaxation response in penile tissue during sexual stimulation, increasing blood flow to help achieve and maintain an erection.
Dapoxetine is a short-acting selective serotonin reuptake inhibitor. It affects serotonin pathways involved in ejaculation control and typically increases time to ejaculation when taken before sex.
These two medicines act on distinct systems, so planning the timing of doses is important. See dosing protocol and administration for practical advice on timing.
Prescription dose and administration
Only take this medicine if prescribed by a qualified clinician. Do not exceed the recommended regimen.
- Swallow the tablet whole with water; do not crush or chew the tablet.
- Food does not prevent the effect, but a fatty meal may delay the onset of sildenafil.
- Common practice: take one tablet roughly one to three hours before sexual activity so dapoxetine reaches effect while sildenafil remains active. Limit to one tablet in any 24 hour period.
- Avoid large amounts of alcohol when using this medicine because intoxication can worsen medication side effects and impair benefit.
- Check pharmacokinetic and pharmacodynamic a mutual exchange of ideass create context for decisions. between drugs if you are taking other medicines before dosing.
If the fixed-dose tablet causes tolerability issues or the timing does not suit your pattern, discuss with your prescriber whether separate treatment for erectile dysfunction and premature ejaculation would be better. See an alternate approach drug classes and similar medications for options to consider.
Drug two-way communication in action management
Many medicines and some foods can alter the safety or effect of sildenafil or dapoxetine. Essential user the act of engaging with otherss drive engagement and learning. to consider include:
- Nitrates and nitric oxide donors: must not be taken with sildenafil because of the risk of severe low blood pressure.
- Strong CYP3A4 inhibitors such as ritonavir, cobicistat, ketoconazole or clarithromycin: these increase concentrations and can raise the incidence of unfavorable health effects.
- Other serotonergic agents (for example some SSRIs, SNRIs, MAO inhibitors, certain triptans, or St. Johns wort): combining these with dapoxetine increases the chance of serotonin syndrome and requires specialist oversight.
- Alpha-blockers and antihypertensive medicines: additive blood pressure lowering can occur; consider time sensitive monitoring and timing adjustments.
- Enzyme inducers like carbamazepine, phenytoin or rifampicin: these may reduce plasma levels and lower efficacy.
- Anticoagulant and antiplatelet agents: SSRIs such as dapoxetine may increase bleeding risk when used with these drugs.
- Certain HIV antivirals: the act of interactions fuel collaboration and innovation. vary by agent; seek specialist advice for people on antiretroviral therapy.
- Grapefruit and grapefruit juice: avoid because they can increase sildenafil exposure.
Reassess the conditions that prevent administration of this treatment that are blanket before starting therapy to find combinations that must never be used.
Safety audits and risk controls
Tell your prescriber about your medical history and current medicines. Pay attention to these conditions:
- Illnesses of the cardiovascular system: coronary artery disease, recent heart attack or stroke, arrhythmias, or any advice to avoid vigorous physical exertion.
- Liver or kidney organ impairment, because elimination of both drugs can be affected.
- Eye disorders including glaucoma or serious retinal disease.
- Current or past severe mood disorders, major depression, bipolar disorder or history of mania.
- Use of strong CYP3A4 inhibitors or ongoing antiviral therapy for HIV or hepatitis.
Ethyl alcohol drink increases the chance of dizziness and low blood pressure and may reduce the benefit of therapy. Dapoxetine can cause lightheadedness on standing; sit or lie down if you feel faint and avoid driving until symptoms resolve.
Older people may be more susceptible to additional effects and should be clinically supervised.
Irreversible this therapy is not suitable under these conditions
- Allergy to sildenafil, dapoxetine or any tablet ingredient.
- Concurrent nitrate therapy or use of nitric oxide donors due to the risk of severe hypotension.
- Unstable cardiovascular disease such as unstable angina or recent myocardial infarction or stroke.
- Severe hepatic insufficiency.
- Retinal pathologies that are inherited, for example retinitis pigmentosa.
- Very low baseline blood pressure or other conditions where vasodilation would be dangerous.
- Uncontrolled psychiatric conditions including active mania.
- Recent or concurrent use of MAO inhibitors without an appropriate washout, unless a specialist advises otherwise.
If you are unsure whether any item applies to you, consult your prescriber and assess the details mitigating steps and safety awareness checks.
Possible undesired effects
Many people tolerate the combination, but undesirable effects can occur. Commonly reported symptoms include:
- Headache disorder with facial flushing signs and dizziness.
- Epigastric distress, nausea or dry mouth.
- Visual changes such as blurred vision or altered color perception.
- Fatigue or increased sweating.
Seek rapid medical care for serious signs:
- Chest pain, sudden major fainting or a marked drop in blood pressure.
- Sudden loss of visual or auditory capacity.
- An erection that lasts longer than four hours (priapism).
- Signs of serotonin syndrome: agitation, high temperature, tremor, fast heartbeat, confusion or excessive sweating.
In Australia, phone 000 for medical emergencies.
What to do when you miss a dose
This medicine is taken as needed. If you miss the planned timing for a sexual occasion, do not take an additional tablet to compensate. Wait until the next appropriate occasion and do not exceed one tablet in any 24 hour period.
If you are taking too much
Signs of take an overdose may include severe dizziness or fainting, very low blood pressure, prolonged erection, flushing, chest discomfort or stomach upset. If you suspect an take an overdose, seek immediate medical assistance or call emergency services on 000 in the Australian continent. Avoid driving until evaluated by a clinician.
Temporary data storage capacity is a key factor in system design. optimization tips
- Keep at room temperature in a dry place, ideally between 15 and 25 degrees Celsius, away from direct heat and moisture.
- Store in the original package and keep out of reach and sight of children and pets.
- Do not use medication beyond the expiry date printed on the pack.
Similar medications and a further option choices
If a combined fixed-dose tablet is unsuitable, clinicians may recommend separate or adjunctive treatments depending on health status, other medicines and patient preference.
- Medication options for erectile dysfunction:
- Generic sildenafil (TGA-registered) or the branded Viagra product.
- Tadalafil (generic) or Cialis brand, for on-demand or low-dose daily use.
- Vardenafil (generic) or Levitra.
- Avanafil (where available, brand Spedra in some markets).
- Non-oral options under specialist care: alprostadil injections, intra-urethral alprostadil or vacuum erection devices.
- Approaches to managing premature ejaculation:
- Dapoxetine (Priligy in some countries) — note dapoxetine is not ARTG-registered in the Australian continent.
- Off-label daily SSRIs such as sertraline, paroxetine or fluoxetine may be prescribed when appropriate.
- Topical anesthetics: lidocaine-prilocaine creams or sprays and numbing condoms.
- Behavioral techniques and psychological therapies: stop-start, squeeze technique and sex therapy.
- Combination strategies:
- Using separate products, for example sildenafil for ED plus an evidence-based PE treatment, can allow dose flexibility and improved tolerability.
Before changing therapycheck this, please. medication mutual interaction notice of risk and consult a prescriber or pharmacist for personalised advice.
Price ranges in Australia labelled AUD - approximate
Costs vary by brand, pack size, pharmacy and whether the product is legitimate and supplied locally or imported. The following are rough retail estimates for budgeting only.
- Extra Super P-Force (imported, unapproved): roughly AUD 3 to 12 per tablet depending on supplier and quantity; quality and legality may be uncertain.
- Generic sildenafil 100 mg (TGA-registered): commonly between AUD 1.50 and 10 per tablet; larger dispensings tend to reduce per tablet cost.
- Viagra 100 mg branded: often around AUD 18 to 40 per tablet at retail pharmacy outlets.
- Tadalafil 10-20 mg generic: around AUD 2 to 12 per tablet; brand Cialis usually costs more.
- Tadalafil 5 mg daily: monthly cost commonly AUD 25 to 80, equivalent to about AUD 0.80 to 2 in descending steps.70 per day.
- Avanafil (Spedra) where available: approximately AUD 12 to 35 per tablet depending on retailer.
- Dapoxetine from overseas suppliers: about AUD 3 to 9 per tablet; note this is not ARTG-registered in Australia and import rules apply.
- Topical lidocaine-prilocaine creams for PE: typically AUD 15 to 40 per tube depending on brand and tube size.
Prices differ as time goes on. For safe supply and valuecompare the outcomes registered Australian pharmacies and discuss options with your pharmacist or doctor.
The status of Australian law and import regulations
- Regulator: the Therapeutic Goods Administration (TGA) is responsible for regulating medicines in the country of Australia.
- Registration and scheduling:
- Sildenafil for erectile dysfunction is normally a Prescription Only Medicine (Schedule 4). A valid prescription from an Australian-registered prescriber is required to obtain TGA-registered products locally.
- Dapoxetine is not listed on the Australian Register of Therapeutic Goods (ARTG). Fixed-dose products such as Extra Super P-Force are not approved by the TGA.
- Personal importation scheme:
- Individuals may import some medicines for personal use under the TGA personal importation provisions if conditions are met. Typical limits include one import no larger than a three month supply and not exceeding a 15 month supply in 12 months.
- For Schedule 4 items, having a valid Australian prescription helps. Clear labelling and recipient name on the package may assist customs clearance.
- Australian Border Force can detain or destroy items that do not comply with import rules or that contain prohibited substances.
- PBS and advertising:
- Most erectile dysfunction therapies are not subsidised on the Pharmaceutical Benefits Scheme for most patients; private payment is usually required.
- Direct-to-consumer advertising of prescription medicines is restricted under Australian law.
- Safety awareness tips: buying from unverified overseas websites increases the risk of counterfeit, substandard or contaminated products. Prefer TGA-registered medicines dispensed by Australian pharmacies when possible.
If you are unsure about importing or using a product, ask your doctor or pharmacist and consult the latest guidance from the TGA.
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