High level summary
The active moiety is dapoxetine hydrochloride. Internationally the tablets are most commonly available in 30 mg and 60 mg strengths; 90 mg tablets are not generally used in routine practice.
This medicine is licensed as a short-term, on-demand treatment for premature ejaculation in adult men. It is not a treatment for erectile dysfunction, although both problems can exist at the same time.
Agile navigation: view how to take charge, titration planning and dose adjustment, safety protocols to consider, online a mutual exchange of ideass connect users across distances., and more options and price guidance.
How does it work? and primary uses
Dapoxetine is a fast-acting selective serotonin reuptake inhibitor designed for single-dose use to delay ejaculation. By briefly elevating serotonin activity in brain circuits involved in ejaculatory control, it can lengthen time to ejaculation and often enhances perceived control and satisfaction.
This product is indicated for premature ejaculation only and should not be used for athletic performance or recovery from anabolic steroids. For timing recommendations refer to how to stomach it.
General guidelines for taking dapoxetine
Always follow the instructions from your prescriber. Practical points commonly recommended include:
- Swallow the tablet whole with a full glass of water; do not crush or chew the tablet.
- Take the dose roughly 1 to 3 hours before sexual activity; many men find about 1 hour is optimal.
- Do not take more than one dose within any 24 hour span.
Additional practical advice:
- Food is optional; a light meal may reduce nausea risk but a heavy meal can delay absorption.
- Avoid excessive alcohol around the time you take the tablet because alcohol increases the chance of dizziness and fainting.
- Avoid grapefruit and grapefruit juice as they can increase blood levels of dapoxetine. If in doubt about timing or safetykindly verify. risk of a drug the networked exchange of ideas hazards and health and safety warning announcements or consult your pharmacist or doctor before first use.
Dosing with titration
Dosing should be tailored to the individual. A typical starting dose is 30 mg taken as needed. If this dose does not produce an adequate response and unintended effects are tolerable, a clinician may increase the dose to 60 mg on demand.
Doses above 60 mg are not routinely advised and increase the likelihood of adverse reactions. Do not alter the dose without consulting your prescriber and do not use dapoxetine daily unless your clinician has specifically recommended continuous therapy.
If treatment response is unsatisfactory, discuss other course options or adjustments with your prescriber; see how to cope with this.
Safety: who should not take dapoxetine
No exception contraindication list
- Known allergy to dapoxetine or any ingredient in the tablet.
- Current or recent use (within 14 days) of monoamine oxidase inhibitors (MAOIs) or plans to start an MAOI within 14 days of stopping dapoxetine.
- Use of thioridazine now or within the last 14 days.
- Receiving linezolid or intravenous methylene blue.
- Concomitant strong CYP3A4 inhibitors such as ketoconazole, itraconazole, ritonavir, saquinavir, nefazodone, or clarithromycin.
- Severe heart disease including uncontrolled conduction problems, unstable ischemia or severe heart failure.
- Severe impairment of the liver.
- Age under 18 years.
If any of the above apply, speak to a healthcare professional before considering dapoxetine. For interacting medicines see drug and potential for growth medication intercommunications create opportunities for collaboration..
Medical conditions to disclose
- History of fainting, low blood pressure, or dehydration.
- Personal or family history of mood disorders including depression, bipolar disorder, mania, or suicidal ideas.
- Epilepsy or any disorder that lowers the seizure threshold.
- Acute angle-closure glaucoma.
- Hepatic impairment or renal impairment, bleeding tendency, or use of anticoagulants.
- Any prescription, over-the-counter, herbal or recreational substances you are taking.
Key safety reminders
- Giddy feeling, lightheadedness and rare fainting have been reported. Rise slowly from sitting or lying positions.
- Avoid alcohol close to dosing. Spirits plus dapoxetine increases risk of sedation and syncope and can impair driving.
- Watch for serotonin syndrome when combining with other serotonergic drugs: agitation, confusion, sweating, fever, tremor, diarrhea, stiffness or fast heart rate. Seek urgent care if suspected.
- SSRIs can raise bleeding risk when used with NSAIDs, aspirin or anticoagulants; report unusual bruising or bleeding.
- Monitor mood and contact a clinician if depression worsens or new suicidal thoughts appear.
- This medicine does not protect against sexually transmitted infections or pregnancy; use condoms or contraception where appropriate.
For emergency signs such as collapse, severe chest pain, seizure or serotonin syndrome, contact emergency services immediately.
Drug the interactional flow among participants considerations
Provide a complete list of your medications to the prescriber. Primary contact and responses create opportunities for collaboration. to review and evaluate include:
- MAOIs and thioridazine are contraindicated because of the risk of severe and life threatening reactions.
- Strong CYP3A4 inhibitors (for example ketoconazole, itraconazole, ritonavir, cobicistat, clarithromycin, nefazodone) markedly increase dapoxetine exposure and should not be combined.
- Other serotonergic agents (SSRIs, SNRIs, TCAs, tramadol, triptans, lithium, St John's wort) raise the risk of serotonin syndrome.
- Moderate inhibitors of CYP3A4 or CYP2D6 such as erythromycin, diltiazem, fluoxetine, paroxetine, bupropion or quinidine may increase unwelcome negative effects; clinicians may adjust dosing or recommend avoidance.
- Alpha-blockers and many antihypertensives may add to the risk of symptomatic low blood pressure.
- Anticoagulants, antiplatelet drugs and NSAIDs may increase bleeding risk when used with dapoxetine.
- PDE5 inhibitors (sildenafil, tadalafil, vardenafil) can compound dizziness or orthostatic symptoms; use only under medical leadership.
- Avoid grapefruit and grapefruit juice because they can elevate dapoxetine levels.
The full list is not shown here. Do not start or stop prescription medicines without first checking with your healthcare provider. See dosing selection and titration for dosing-related concerns.
Unforeseen effects that may occur
Many men tolerate dapoxetine at recommended doses, but detrimental health effects can occur.
Common or insignificant reactions
Examples include nausea, dizziness, pain of the head, diarrhea, dry mouth, sweating, flushing, trouble sleeping, drowsiness, fatigue, tremor, mild anxiety or decreased appetite. If effects persist or become troublesome, stop and consult your prescriber to consider dose changes or a different option strategies. See titration and dose adjustment.
Reactions of a serious nature needing immediate attention
Seek immediate medical help for fainting, prolonged severe lightheadedness, seizures, symptoms of serotonin syndrome (very high fever, severe agitation, rigid muscles, rapid heartbeat), severe allergic swelling of the face or throat, or unexplained significant bleeding or black stools.
If you suspect an adverse drug reaction, tell your clinician and consider reporting the event to the Therapeutic Goods Administration (TGA).
Best ways to store items
Store tablets at room temperature in a dry place away from heat and direct sunlight. Do not allow children to reach medicines. When transporting or importing, retain original packaging and accompanying documentation where possible. For importation rules see australia's status of being legally recognized.
Other options and estimated transparent pricing within Australia (AUD)
Non-drug options and other possible treatments
- Behavioral techniques such as the start-stop or squeeze methods and formal psychosexual therapy can provide durable benefits.
- Topical anesthetic agents containing lidocaine or prilocaine applied to the penis to reduce sensation.
- Oral SSRIs used off-label for premature ejaculation (for example sertraline, paroxetine, fluoxetine) are usually given daily rather than on demand.
- PDE5 inhibitors such as sildenafil or tadalafil may help men with coexisting erectile dysfunction and can be combined with other approaches under clinician advice.
- Tramadol tablet has been used off-label for some patients but carries opioid related risks and is not first-line.
Approximate price category ranges (AUD)
- Generic dapoxetine obtained via personal importation: approximately AUD 2 to 6 per 30 mg tablet depending on supplier, quantity and postage.
- Branded Priligy from overseas suppliers: roughly AUD 8 to 20 per tablet depending on exchange rates and vendor.
- Generic SSRIs for off-label PE: costs vary; typical monthly generic supplies may be about AUD 10 to 30 depending on dose and PBS eligibility.
- Topical anesthetic creams or sprays: about AUD 20 to 50 per pack depending on brand and size.
- Sildenafil generics at discount pharmacies: from around AUD 1 to 5 per tablet; branded sildenafil commonly costs AUD 15 to 25 per tablet.
Prices vary by pharmacy, pack size, brand and any government subsidy. The figures above are indicative only. For details on access see access rights and standing under the law.
Access and status of being legally authorized within Australia
- The Therapeutic Goods Administration (TGA) oversees medicine regulation across Australia. Many sexual health medicines are Schedule 4 and require a prescription.
- Dapoxetine is not commonly registered on the Australian Register of Therapeutic Goods (ARTG) for premature ejaculation and is not listed on the Pharmaceutical Benefits Scheme (PBS) for this indication.
- Clinicians may recommend registered choice a backup options or consider special access pathways when appropriate.
- Under personal importation rules, individuals may import up to a three month supply for personal use subject to conditions. Imported medicines should normally remain in original packaging and be accompanied by a valid Australian prescription; customs can seize noncompliant shipments.
- Purchasing from overseas internet sellers carries risks of counterfeit or substandard products. Australian law also limits direct-to-consumer advertising of prescription medicines.
- If you experience drowsiness or dizziness while taking a medicine, avoid driving or operating machinery and follow any workplace reporting obligations.
For up to date regulatory guidance consult the TGA website or speak with your doctor or pharmacist. Find related material price points and varied options and hazard safety hazard alerts.
Handy tips and useful links
- Consider combining medication with behavioral methods and, where helpful, sex therapy for best results.
- If unwanted effects are troublesome, pause dosing and contact your prescriber to discuss dose, timing or other forms of therapy; see dosing planning with titration.
- Always look over everything. for potential potential medication conversational exchange possibilities before starting or after any medicine change.
- If you suspect a serious adverse eventthe review process workplace safety notifications of danger and call emergency services if necessary.
- Reliable Australian sources include the TGA consumer pages at www.tga.gov.au and general health information at www.healthdirect.gov.au.
- Report adverse reactions to the TGA Adverse Event Reporting system to help monitor medicine safety.
Extra information
Pharmacological class: a short-acting selective serotonin reuptake inhibitor formulated for on-demand use in premature ejaculation.
Brand name most commonly seen internationally: Priligy. Availability and trade names differ by country and supplier.
Related topics to explore: long term management of premature ejaculation, approaches when erectile dysfunction coexists, and safe procedures for personal importation of medicines. For dosing and safety details see dosage management and titration and safety danger alerts should be followed.
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